李国
副教授
个人简介：李国，博士研究生，副教授，硕士生导师，教育部全国研究生教育评估监测专家库专家，主要从事溶酶体损伤介导多级免疫调控和硼中子俘获治疗及其放射生物学机制研究。主持国家自然科学基金青年项目一项，参与国家重点研发计划、国家级人才项目、江苏省杰出青年基金项目等项目。以第一作者、通讯作者（含共同）在Advanced Materials、Research、ACS Materials Letters、Chemical Communications（封面文章）等国际著名期刊上发表学术论文30余篇，申请国家专利20余项。担任Proceedings of the National Academy of Sciences of the United States of America, Advanced Science, Analytical Chemistry, Chemical Science, Chemical Communications等杂志审稿人。担任TransMed杂志青年编委，《365英国上市集团学报（自然科学版）》青年编委，获评365英国上市集团学报2024年度“优秀青年编委”。指导学生获得研究生国家奖学金、腾讯奖学金、优秀毕业生、江苏省实践大赛二等奖等。
课题组主页：李国 (ntu.edu.cn)
研究方向：硼中子俘获治疗及其放射生物学机制研究，新型生物医学检测技术，荧光共聚物量子点、光学探针及其生物医学应用。
招生方向：公共卫生与预防医学，公共卫生，卫生检验，医学检验技术。
科研项目：
1. 国家自然科学基金青年基金，智能化级联响应聚合物光疗试剂用于非小细胞肺癌精准高效治疗，2022.01-2024.12，结题，主持。
2. 国家重点研发计划青年科学家项目，多模态诊疗一体化硼药设计及其多重抗肿瘤机制研究，2024.12-2029.11，在研，骨干成员。
3. 国家级人才项目（青年），肿瘤精准治疗需求牵引下的生物医学检验新技术研究，2022.01-2024.12，结题，骨干成员。
4. 国家自然科学基金面上项目，基于多色免疫组织化学的肿瘤免疫微环境分析新技术研究，2022.01-2025.12，结题，骨干成员。
5. 江苏省杰出青年基金项目，骨干成员。
代表论文：
(1) Guo Li, Yingqi Gao, Kun Qian, Minfeng Yang, Mingmin Wu, Qi Wang, Xiaobo Zhou, Rui Xia, Yuling Qin* and Li Wu*. Sulfur-or Selenium-substituted Nile Blue-based Superoxide Radical Generator for Precise Photodynamic Therapy and Immunotherapy, Chem. Commun, 2026, 62, 2788-2799 (Nature Index).
(2) Shijie Li, Linyi Shi, Xiaobo Zhou*, Ke Zhang, Lingfeng Zhao, Zhonghao Chen, Guo Li, Yuling Qin* and Li Wu*, Construction of bright color-tunable chemiluminescent nanodots and their applications for in vivo bioimaging, Chem. Commun, 2026, 62, 3387-3390 (Nature Index).
(3) Liuwei Gu, Yongxiao Xu, Xiaojie Kong,Guo Li *, Yulin Qin* and Li Wu*, Phased-Change Materials BasedImmunomodulator for Cascade-ActivatableTumor-Specific Photoimmunotherapy,ACS Mater. Lett.,2024, 6, 5392-5401(中科院一区).
(4) Guo Li,Liuwei Gu, Chaojie Yang, Xiaojie Kong, Yuling Qin* and Li Wu*, Lysosome-Anchoring Activation Design of Type I Photosensitizer Evokes Pyroptosis and Antitumor Immunity, ACS Mater. Lett.,2024,6,1820-1830(中科院一区).
(5) Liuwei Gu, Xiaojie Kong, Mengyan Li, Rui Chen, Ke Xu, Guo Li*,Yulin Qin* and Li Wu*,Molecule engineering strategy of toll-like receptor 7/8 agonists designed for potentiate immune stimuli activation, Chem. Commun., 2024, 60, 5474-5485 (Nature Index).
(6) Guo Li, Mingmin Wu, Yongxiao Xu, Qi Wang, Jinxia Liu, Xiaobo Zhou, Haiwei Ji, Qu Tang, Xijuan Gu,Shujuan Liu, Yuling Qin,* Li Wu,* andQiang Zhao*, Recent progress in the development of singlet oxygen carriers forenhanced photodynamic therapy, Coord. Chem. Rev.,2023, 478: 214979(中科院一区).
(7) Guo Li, Yongxiao Xu, Xiaojie Kong, Liuwei Gu, Yuling Qin,* and Li Wu,* NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy, Chem. Commun., 2023, 59,6343-6346(Nature Index).
(8) Liuwei Gu, Yinghao Li, Xiaojie Kong, Ke Zhang, Yuling Qin, Xiaobo Zhou*, Haiwei Ji*, Guo Li*, and Li Wu. A stable ratiometric fluorescent probe for hypochlorous acid detection and rheumatoid arthritis evaluation. Biomater. Sci., 2024, 12, 330 (中科院二区).
(9) Zhonghao Chen, Hongyi Liu, Yan Ge, Yuhan Zeng, Shijie Li, Linyi Shi, Guo Li*, Qi Wang*, Xiaobo Zhou*. Fluorinated complexes doped nanodot with high brightness and dual emission for ratiometric detection of glucose-related enzymes.J. Lumin., 2024, 271, 120579(中科院三区).
(10) Jinxia Liu, Luxia Yang, Shijie Li, Ke Zhang, Xiaobo Zhou, Guo Li, Li Wu*, Yuling Qin*, Near-infrared electrochemiluminescence biosensors facilitated by thermally activated delayed fluorescence (TADF) emitters for ctDNA analysis,Biosens. Bioelectron., 2024,251, 116103.
(11) Majun Yang, Weida Zhu, Yilin Lv, Bin Jiang, Chenxia Jiang, Xiaobo Zhou, Guo Li, Yuling Qin, Qi Wang,* Ziwei Chen,* Li Wu,* A Dual-Responsive Ratiometric Indicator Designed for in Vivo Monitoring of Oxidative Stress and Antioxidant Capacity, Chem.Sci., 2023, 14, 12961-12972 (Nature Index).
(12) Ke Zhang, Xiaobo Zhou,* Shijie Li, Lingfeng Zhao, Wenqi Hu, Aiting Cai, Yuhan Zeng, Qi Wang, Mingmin Wu, Guo Li, Jinxia Liu, Haiwei Ji, Yuling Qin,* Li Wu,* A General Strategy for Developing Ultrasensitive “Transistor-like” Thermochromic Fluorescent Materials for Multilevel Information Encryption, Adv. Mater., 2023,35, 2305472 (Nature Index).
(13) Haiwei Ji, Xiaoxia Kang, Xiaoxiao Yang, Huanhuan Chen, Tianzhi Mao, Yue He, Jinxia Liu, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Hui Cong, Li Wu*, Yuling Qin*, Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease, Biosens. Bioelectron., 2023, 222, 114927.
(14) Xiaobo Zhou, Yuhan Zeng, Shijie Li, Ke Zhang, Lingfeng Zhao, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin, Wei Feng, Fuyou Li*, Li Wu*, Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo, J. Mater. Chem. B., 2023, 11, 11217-11221.
(15) Chaojie Yang, Chenxia Jiang, Majun Yang, Qingqing Bai, Yaya Zhen, Yuxue Zhang, Weiyi Yin, Jian Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, Haiwei Ji*, and Li Wu*, NAD(P)H Activated Fluorescent Probe for Rapid Intraoperative Pathological Diagnosis and Tumor Histological Grading, Chem. Biomed. Imaging, 2023, 1, 738-749.
(16) Xiaobo Zhou*, Lingfeng Zhao, Ke Zhang, Chaojie Yang, Shijie Li, Xiaoxia Kang, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin* and Li Wu*, Ultrabright AIEdots with tunable narrow emission for multiplexed fluorescence imaging.Chem. Sci., 2023, 14,113-120(Nature Index).
(17) Qingqing Bai, Chaojie Yang, Majun Yang, Zhaoqing Pei, Xiaobo Zhou, Jinxia Liu, Haiwei Ji, Guo Li Mingmin Wu, Yuling Qin, Qi Wang*, and Li Wu*, pH-Dominated selective imaging of lipid droplets and mitochondria via a polarity-reversible ratiometric fluorescent probe. Anal. Chem. 2022, 94, 2901-2911 (Nature Index).
(18) Jinxia Liu, Xiaodi Liu, Huanhuan Chen, Luxia Yang, Aiting Cai, Haiwei Ji*, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin*and Li Wu*, Bifunctional pdots-based novel ECL nanoprobe with qualitative and quantitative dual signal amplification characteristics for trace cytokine analysis. Anal. Chem. 2022, 94, 7115-7122 (Nature Index).
(19) Linfeng Zhao, Can Zhao, Jiasheng Zhou, Yuling Qin, Guo Li*, Li Wu* and Xiaobo Zhou*, Conjugated polymers-based luminescent probes for ratiometric detection of biomolecules, J. Mater. Chem. B.,2022, 10, 7309-7327.
(20) Jinxia Liu, Xiaodi Liu, Luxia Yang, Aiting Cai, Xiaobo Zhou*, Chu Zhou, Guo Li, Qi Wang, Mingmin Wu, Li Wu, Haiwei Ji*and Yuling Qin*,A highly sensitive electrochemical cytosensor based on a triple signal amplification strategy using both nanozyme and DNAzyme, J. Mater. Chem. B,2022, 10, 700-706.
(21) Guo Li, Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin*, Xiaobo Zhou*and Li Wu*, Innovative strategies for enhanced tumor photodynamic therapy, J. Mater. Chem. B,2021, 9, 7347-7370.
(22) Guo Li, Xiangxiang Zhang, Weili Zhao, Weiwei Zhao, Feiyang Li, Kang Xiao, Qi Yu, Shujuan Liu*, and Qiang Zhao*, Stable and well-organized near-infrared (NIR) platinum(II)-acetylide metallacycles mediated cancer phototherapy, ACS Appl. Mater. Interfaces,2020, 12, 20180-20190.
(23) Guo Li, Ruyi Zhou, Weili Zhao, Bo Yu, Jie Zhou, Shujuan Liu*, Wei Huang*, and Qiang Zhao*, Photothermally-responsive conjugated polymeric singlet oxygen carrier for phase-change-controlled and sustainable phototherapy for hypoxic tumor,Research,2020, 5351848.
(24) Guo Li, Wenbo Hu, Menglong Zhao, Weili Zhao, Feiyang Li, Shujuan Liu*, Wei Huang, and Qiang Zhao*, Rational design of near-infrared platinum(II)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation,J. Mater. Chem. B,2020, 8, 7356-7364.
(25) Xue Liu, Guo Li, Mingjuan Xie, Song Guo, Weili Zhao, Feiyang Li, Shujuan Liu*, and Qiang Zhao*, Rational design of type I photosensitizers based on Ru(II) complexes for effective photodynamic therapy under hypoxia, Dalton Trans., 2020, 49, 11192-11200.
(26) Guo Li, Tianci Huang, Mingjuan Xie, Xiangxiang Zhang, Qi Yu,Shujuan Liu*, Tianshe Yang, andQiang Zhao*, A platinum(II)-acetylide-based conjugated polyelectrolyte for hypoxia imaging via ratiometric and time-resolved luminescence microscopy, J. Organomet. Chem, 2019, 879: 144-149.
(27) Guo Li, Tianshe Yang, Weiwei Zhao, Shujuan Liu, Wei Huang, Qiang Zhao*, Luminescent conjugated polymer dots for biomedical applications, Springer Book Frontiers of Nanophotonics in Biomedical Engineering. (chapter)
(28) Qi Yu, Tianci Huang, Chao Liu, Menglong Zhao, Mingjuan Xie, Guo Li, Shujuan Liu, Wei Huang* and Qiang Zhao*, Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy, Chem. Sci. 2019, 10, 9091-9098 (Nature Index).
(29) Yunjian Xu, Teng Feng, Tianshe Yang, Huanjie Wei, Huiran Yang, Guo Li, Menglong Zhao, Shujuan Liu*, Wei Huang*, and Qiang Zhao*, Utilizing intramolecular photoinduced electron transfer to enhance photothermal tumor treatment of aza-BODIPY-based near-infrared nanoparticles, ACS Appl. Mater. Interfaces, 2018, 10, 16299-16307.
获得奖项：
1. 李国刺激响应型光学探针用于肿瘤光-免疫治疗, 中国微米纳米技术学会微纳传感技术与检测创新论坛（2023）, 厦门, 2023-11-18至2023-11-20 会议报告
2. 李国刺激响应型光学探针用于肿瘤光-免疫治疗, 第十六届全国化学传感器学术会议（SCCS2023）, 济南, 2023-9-22至2023-9-24 会议报告
3. 江苏省研究生生物安全技术与促进创新实践大赛二等奖指导老师, 江苏省理学2类研究生教育指导委员会
4. 2024年研究生国家奖学金指导老师 2024-12 中华人民共和国教育部
5．2024年腾讯奖学金指导老师 2024-10 中国教师发展基金会
